Do not administer unless solution is clear. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. I found this out recently from my son's doctor. To report SUSPECTED ADVERSE REACTIONS, contact Mylan at 1-877-446-3679 (1-877-4-INFO-RX) or FDA at 1-800-FDA-1088 or, Magnesium Sulfate heptahydrate injection, solution, We comply with the HONcode standard for trustworthy health information -. If you have any questions, ask your doctor or pharmacist.. Subcutaneous physostigmine, 0.5 to 1 mg may be helpful. Higher temperatures lead to greater losses. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 3 Dec 2020) and others. Information about your device and internet connection, including your IP address, Browsing and search activity while using Verizon Media websites and apps. 5 years ago. In addition, cases of neonatal fracture have been reported. Magnesium sulfate is one type of magnesium supplement that can help treat symptoms of magnesium deficiency like muscle cramps, fatigue and irritability — plus other common health problems, too, such as constipation. Because magnesium is removed from the body solely by the kidneys, the drug should be used with caution in patients with renal impairment. The safety and efficacy of such use have not been established. It has a role as an anticonvulsant, a cardiovascular drug, a calcium channel blocker, an anaesthetic, a tocolytic agent, an anti-arrhythmia drug, an analgesic and a fertilizer. Magnesium Chloride G Magnesium Sulfate G Maleic Acid D Methanol L N-Methyl-2-Pyrrolidone L N,N Dimethylformamide L Nitric Acid E P-Dioxane L Paraformaldehyde L ... primary focus is concerning flammable liquids, flammable gases and Extremely/Acutely/Severally Toxic materials. Been working two jobs on it. Use a mercury free magnesium sulfate cream ( Kirkman's Labs) sells this. The shortest duration of treatment that can lead to fetal harm is not known. Flame temperatures of magnesium and magnesium alloys can reach 3,100 °C (5,610 °F), although flame height above the burning metal is usually less than 300 mm (12 in). Magnesium sulfate, anhydrous >99 7487-88-9 231-298-2 MgSO 4 120.37 g/mol 4. To enable Verizon Media and our partners to process your personal data select 'I agree', or select 'Manage settings' for more information and to manage your choices. Magnesium Sulfate, USP heptahydrate is chemically designated MgSO4 • 7H2O, colorless crystals or white powder freely soluble in water. For the management of pre-eclampsia or eclampsia, intravenous infusions of dilute solutions of magnesium (1% to 8%) are often given in combination with intramuscular injections of 50% Magnesium Sulfate Injection. Specific hazards arising from In severe pre-eclampsia or eclampsia, the total initial dose is 10 to 14 g of Magnesium Sulfate. It is available in 4% concentration. Cyclosporine If swallowed DO NOT induce vomiting. SAFETY DATA SHEET: MAGNESIUM SULFATE, HEPTAHYDRATE MAGNESIUM SULFATE, HEPTAHYDRATE M232.10; M232.32 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 In magnesium: Principal compounds. Drug induced renal losses of magnesium occur with the following drugs or drug classes: Aminoglycosides Magnesium exposed to moist fluorine or chlorine is spontaneously flammable [Mellor 4:267. It is available in 4% concentration. Yahoo is part of Verizon Media. Reflexes may be absent at 10 mEq magnesium/liter, where respiratory paralysis is a potential hazard. However, other effective drugs are available for this purpose. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. A mixture of finely divided magnesium and nitric acid is explosive [Pieters 1957. p 28]. A serum magnesium level of 6 mg/100 mL is considered optimal for control of seizures. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. FIRST-AID MEASURES Eyes Rinse with plenty of water for at least 15 minutes and seek medical attention if necessary. Magnesium Sulfate Safety Data Sheet According to the Hazard Communication Standard (29 CFR 1910.1200) SECTION 1: Product and Company Identification Product identifier Magnesium sulfate Other means of identification None Synonym(s) None Recommended use Agriculture fertilizer Recommended restrictions None known. Low magnesium levels don't cause symptoms in the short term. 3 Product Name: Magnesium Sulfate Injection, USP Respiratory Protection Respiratory protection is not needed during normal product use. WARNING: DO NOT USE FLEXIBLE CONTAINER IN SERIES CONNECTIONS. Magnesium acts peripherally to produce vasodilation. Fire Extinguishing Media : Use any means suitable for extinguishing surrounding fire. 77, No. Therapy should continue until paroxysms cease. The strength of the deep tendon reflexes begins to diminish when serum magnesium levels exceed 4 mEq/liter. If this drug is used during pregnancy the woman should be apprised of the potential harm to the fetus. Magnesium sulfate, MgSO 4, is a colourless crystalline substance formed by the reaction of magnesium hydroxide with sulfur dioxide and air.A hydrate form of magnesium sulfate called kieserite, MgSO 4 ∙H 2 O, occurs as a mineral deposit. These bone abnormalities include skeletal demineralization and osteopenia. Epsom salts is magnesium sulfate or magnesium sulfate heptahydrate, also known as sulfur bitter, bitter... What else can I do help heal my mild to moderate sprained ankle ? Magnesium Sulfate, 2.25% w/v Safety Data Sheet according to Federal Register / Vol. Select one or more newsletters to continue. dose, some clinicians administer 1 to 2 g/hour by constant I.V. Disappearance of the patellar reflex is a useful clinical sign to detect the onset of magnesium intoxication. The adverse effects of parenterally administered magnesium usually are the result of magnesium intoxication. Last updated on Oct 1, 2020. If not breathing, give artificial respiration. [See USP Controlled Room Temperature.] Pain. No dosing adjustments are necessary in hepatic insufficiency. infusion. Digitalis Amphotericin B Larne, United Kingdom, clonazepam, lamotrigine, diazepam, topiramate, Lamictal, Valium, magnesium oxide, sotalol, acebutolol, Betapace. Water for Injection, USP is chemically designated H2O. For advice, contact the … Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration. Epsom Salts contain mercury. Magnesium Sulfate in Water for Injection is a sterile, nonpyrogenic, clear, colorless solution of Magnesium Sulfate heptahydrate in water for injection. A mixture of finely divided magnesium and nitric acid is explosive [Pieters 1957. p. 28]. Parenteral use in the presence of renal insufficiency may lead to magnesium intoxication. When administered by continuous IV infusion (especially for more than 24 hours preceding delivery) to control convulsions in a toxemic woman, the newborn may show signs of magnesium toxicity, including neuromuscular or respiratory depression. Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. The flexible plastic container is fabricated from polypropylene. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Contact may cause irritation to eye, skin, and respiratory system. DOT Classification: CLASS 4.1: Flammable solid. Date Prepared: April 5, 2012. Continuous administration of Magnesium Sulfate is an unapproved treatment for preterm labor. Monitoring serum magnesium levels and the patient’s clinical status is essential to avoid the consequences of overdosage in toxemia. Skin Protection If solution contact with unprotected skin is likely, use of impervious gloves is a prudent practice. Alcohol Magnesium intoxication is manifested by a sharp drop in blood pressure and respiratory paralysis. The central and peripheral effects of magnesium poisoning are antagonized to some extent by intravenous administration of calcium. Continuous maternal administration of Magnesium Sulfate in pregnancy beyond 5-7 days can cause fetal abnormalities. An injectable calcium salt should be immediately available to counteract the potential hazards of magnesium intoxication in eclampsia. Identification: : Magnesium UNNA: 1869 PG: III Special Provisions for Transport: Not available. Special protective equipment and precautions for firefighters Wear self-contained, approved breathing apparatus and full protective clothing, including eye protection and boots. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. I'm wearing an air cast for it. Magnesium sulfate is a magnesium salt having sulfate as the counterion. Magnesium Sulfate in Water for Injection is a sterile, nonpyrogenic, clear, colorless solution of Magnesium Sulfate heptahydrate in water for injection. Fire: Magnesium Sulfate is not flammable. Extinguishing Media: This material is compatible with all extinguishing media. We and our partners will store and/or access information on your device through the use of cookies and similar technologies, to display personalised ads and content, for ad and content measurement, audience insights and product development. Mylan Institutional LLC May contain sulfuric acid and/or sodium hydroxide for pH adjustment. Effective anticonvulsant serum levels range from 2.5 to 7.5 mEq/liter. Fireworks use magnesium, both in aerial fireworks and in hand-held sparklers. Because many drugs are excreted in human milk, caution should be exercised when Magnesium Sulfate in Water for Injection is administered to a nursing mother. Clinical indications of a safe dosage regimen include the presence of the patellar reflex (knee jerk) and absence of respiratory depression (approximately 16 breaths or more/minute). Urine output should be maintained at a level of 100 mL every four hours. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. Inhalation Move casualty to fresh air and keep at rest. Hypermagnesemia in the newborn may require resuscitation and assisted ventilation via endotracheal intubation or intermittent positive pressure ventilation as well as IV calcium. : Magnesium Rhode Island RTK hazardous substances: Magnesium Pennsylvania Started to soak it in Epsom salts. Magnesium Sulfate in Water for Injection should be administered slowly to avoid producing hypermagnesemia. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period. Relevant identified uses of the substance or mixture and uses advised against Use of the substance/mixture : Laboratory chemicals 1.3. Synthetically prepared magnesium sulfate is sold as Epsom salt, MgSO 4 ∙7H 2 O. In… Powdered magnesium reacts violently with performic acid [Berichte 48:1139. Cool unopened containers with water. In the event of overdosage, artificial ventilation must be provided until a calcium salt can be injected IV to antagonize the effects of magnesium. Thermal decomposition of Magnesium Sulfate Heptahydrate produces irritating vapors and toxic gases (e.g. Synonyms : Magnesium / magnesium, borings / magnesium, metal / magnesium, ribbons / magnesium, scalpings / magnesium, sheet / magnesium, turnings BIG no : 10761 1.2. Medically reviewed by Drugs.com. Follow all directions on the product package. Flammable limits: This material is noncombustible. Diuretics Intravenous magnesium should not be given to mothers with toxemia of pregnancy during the two hours preceding delivery. Magnesium Sulfate in Water for Injection is intended for intravenous use only. Approximately 1-2% of total body magnesium is located in the extracellular fluid space. If Magnesium Sulfate is given for treatment of preterm labor, the woman should be informed that the efficacy and safety of such use have not been established and that use of Magnesium Sulfate beyond 5-7 days may cause fetal abnormalities. Magnesium Sulfate should be used during pregnancy only if clearly needed. 0 0. Discard unused portion. Artificial respiration is often required. Cisplatin. Magnesium Sulfate Heptahydrate is an odorless, colorless to white solid in crystalline form. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. You can change your choices at any time by visiting Your Privacy Controls. Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. Available for Android and iOS devices. It is a magnesium salt and a metal sulfate. Eye Protection Eye protection is not required during expected product use conditions but may be warranted should a splash potential exist. Intravenously administered magnesium is immediately absorbed. At this level respiratory paralysis may occur. Magnesium is excreted solely by the kidney. And if someone is shooting heat-seeking missiles at you, you’d better hope magnesium is flammable: Beyond saving the life of hikers and military pilots, magnesium is also used in signal flares, such as road flares, though other fuels (such as aluminum) are also used. Belongs to the Following Reactive Group (s) Metals, Elemental and Powder, Active If any item is not applicable or no information is available, the space must be marked to indicate that. Following intramuscular administration the onset of action occurs in about one hour and persists for three to four hours. See HOW SUPPLIED section for the content and characteristics of available dosage forms and sizes. Sulfate mgo board is also known as MGSO4 board, magnesium sulfate board or chloride free mgo board which is a light weight non-flammable panel product. After the initial I.V. Magnesium exposed to moist fluorine or chlorine is spontaneously flammable [Mellor 4:267. Chloride Free MGO Board is made from magnesium oxide, magnesium sulfate, Wood fiber, Perlite, Small glass cloth and others. Magnesium is said to have a depressant effect on the central nervous system, but it does not adversely affect the mother, fetus or neonate when used as directed in eclampsia or pre-eclampsia. If breathing is difficult, give oxygen. (See OVERDOSAGE.). Fiber cement panels are non-combustible building materials and offer amazing performance in fireproof, bending strength and impact resistance. Magnesium Sulfate in Water for Injection, can cause fetal abnormalities when administered beyond 5-7 days to pregnant women. infusion should generally not exceed 150 mg/minute, or 3.75 mL of a 4% concentration (or its equivalent) per minute, except in severe eclampsia with seizures. 1946-47]. To report SUSPECTED ADVERSE REACTIONS, contact Mylan at 1-877-446-3679 (1-877-4-INFO-RX) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. The pH is 4.5 (3.5 to 6.5). Product is not flammable. Magnesium Sulfate Heptahydrate is not flammable or reactive. Magnesium is highly flammable, especially when powdered or shaved into thin strips, though it is difficult to ignite in mass or bulk. Immediate medical attention and special treatment, if necessary No additional information available … The administration of Magnesium Sulfate in Water for Injection outside of its approved indication in pregnant women should be by trained obstetrical personnel in a hospital setting with appropriate obstetrical care facilities. Generic Name: Magnesium Sulfate heptahydrate Magnesium Sulfate, Created by Global Safety Management, Inc. -Tel: 1-813-435-5161 - www.gsmsds.com Methods and material for containment and cleaning up: If in a laboratory setting, follow Chemical Hygiene Plan procedures.Place into properly labeled containers for recovery or disposal. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. If you have rectal bleeding or if you do not have a bowel movement after using magnesium sulfate as a laxative, stop using the medication and call your doctor at once. A total daily (24 hr) dose of 30 to 40 g Magnesium Sulfate should not be exceeded. Find out more about how we use your information in our Privacy Policy and Cookie Policy. Magnesium sulfate taken orally should produce a bowel movement within 30 minutes to 6 hours. Anonymous. Is Magnesium Sulfate Flammable. Simultaneously, 4 to 5 g (32.5 to 40.6 mEq) of Magnesium Sulfate may be administered intramuscularly into each buttock using undiluted 50% Magnesium Sulfate Injection. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Virtually every part of our bodies — including our cells, nerves, muscles, bones and hearts — require a steady supply of the nutrient magnesium to maintain normal functioning. Therefore, in the clinical conditions cited below, both forms of therapy are noted, as appropriate. Magnesium Sulphate Page 2 of 4 Ingestion: Never give anything by mouth to an unconscious person. Prevent contact with skin and eyes. With low doses only flushing and sweating occur, but larger doses cause lowering of blood pressure. Section I Manufacturer’s name North Country Organics Emergency Telephone Number 802-222-4277 How to use Magnesium Sulfate. Magnesium (Mg++) is an important cofactor for enzymatic reactions and plays an important role in neurochemical transmission and muscular excitability. Magnesium plays many crucial roles in the body, such as supporting muscle and nerve function and energy production. Hypocalcemia with signs of tetany secondary to Magnesium Sulfate therapy for eclampsia has been reported. Rockford, IL 61103 U.S.A. Explosion : It is not considered to be an explosion hazard. Section 15: Other Regulatory Information Federal and State Regulations: Connecticut hazardous material survey. Page: 1 of 3 . Magnesium Sulfate in Water for Injection is supplied as a clear, colorless solution in single-dose flexible plastic container as follows: * Partial fill container 50 mL volume in 100 mL container. Magnesium is a mineral found in the earth, sea, plants, animals and humans. Heart block also may occur at this or lower serum levels of magnesium. Drink plenty of liquids while you are taking magnesium sulfate. Protect from freezing. Studies with Magnesium Sulfate in Water for Injection have not been performed to evaluate carcinogenic potential, mutagenic potential or effects on fertility. Hazards to fire-fighters: See Section 3 for information on hazards when this material is present in the area of a fire. Magnesium is 30% bound to albumin. FETAL HARM: Continuous administration of Magnesium Sulfate beyond 5-7 days to pregnant women can lead to hypocalcemia and bone abnormalities in the developing fetus. Potassium Magnesia Sulfate Note: Blank spaces are not permitted. Store at 20° to 25°C (68° to 77°F). Subsequent intramuscular doses of 4 to 5 g of Magnesium Sulfate may be injected into alternate buttocks every four hours, depending on the continuing presence of the patellar reflex, adequate respiratory function, and absence of signs of magnesium toxicity. Use appropriate media for adjacent fire. Source(s): https://owly.im/a723z. Been elevating foot when possible. To initiate therapy, 4 g of Magnesium Sulfate in Water for Injection may be administered intravenously. 1. 1946-47]. sulfur oxides). With intravenous administration the onset of anticonvulsant action is immediate and lasts about 30 minutes. MATERIAL SAFETY DATA SHEET . There are retrospective epidemiological studies and case reports documenting fetal abnormalities such as hypocalcemia, skeletal demineralizations, osteopenia and other skeletal abnormalities with continuous maternal administration of Magnesium Sulfate for more than 5-7 days.1-12 Magnesium Sulfate in Water for Injection should be used during pregnancy only if clearly needed. Manufactured by: Intravenous calcium, 10 to 20 mL of a 5% solution (diluted if desirable) with isotonic sodium chloride for injection) is used to counteract effects of hypermagnesemia. It is a new type non-flammable material made of light weight materials. Magnesium is excreted solely by the kidney. Trade Name: Epsom Salt, Magnesium Sulfate, U.S.P. In the presence of severe renal insufficiency, frequent serum magnesium concentrations must be obtained and the maximum dosage of Magnesium Sulfate is 20 g per 48 hours. The pH is 4.5 (3.5 to 6.5). Dosage Form: injection, solution. Terumo BCT Ltd 58 / Monday, March 26, 2012 / Rules and Regulations 11/08/2017 EN (English US) 2/6 4.3. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in … Normal serum magnesium levels range from 1.3 to 2.1 mEq/liter. 1915]. It is not known whether this drug is excreted in human milk. However, chronically low levels can increase the risk of high blood pressure, heart disease, type 2 diabetes and osteoporosis. Serum magnesium levels usually sufficient to control convulsions range from 3 to 6 mg/100 mL (2.5 to 5 mEq/liter). The rate of I.V. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Manufactured for: Take this product by mouth as directed. As serum magnesium rises above 4 mEq/liter, the deep tendon reflexes are first decreased and then disappear as the serum level approaches 10 mEq/liter. In patients with severe renal insufficiency, the dose should be lower and frequent serum magnesium levels must be obtained (see DOSAGE AND ADMINISTRATION). OSHA Vacated PELs: Magnesium sulfate, anhydrous: No OSHA Vacated PELs are listed for this chemical.
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